folate level greater than 20

[, Greenberg JA, Bell SJ, Guan Y, et al. In folate deficiency, homocysteine levels are elevated and MMA levels are normal. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Consult with your healthcare professional before consuming a folate supplement when you are taking anticonvulsant medication. Common dietary sources of folate include cereals, leafy green vegetables, asparagus, legumes and organ meat. J Clin Psychiatry 2004;65:1090-5. Therefore, we sought to Folic Acid. 2009 Nov 18. Anemia due to folate deficiency Megaloblastic anemia Risks There is very little risk involved with having your blood taken. Serum folate levels typically fall Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. Folate is naturally present in a wide variety of foods, including vegetables (especially dark green leafy vegetables), fruits and fruit juices, nuts, beans, peas, seafood, eggs, dairy products, meat, poultry, and grains (Table 2) [4,12]. Additional research is needed to fully understand the association between folate status and depression. Bokhari SW, Bokhari ZW, Zell JA, Lee DW, Faxon DP. How to differentiate between UTI and Pregnancy Symptoms? 1997 Apr 1. In many cases, it's high because a person is eating a diet rich in folic acid. Folate deficiency is lack of folic acid, which is a B group vitamin found in small amounts in many foods usually absorbed through the small intestine. Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. When you have anemia, your blood cant bring enough oxygen to all your tissues and organs. 11th ed. Cantarella CD, Ragusa D, Giammanco M, Tosi S. Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature. for: Medscape. An inadequate level of folate in the body, called folate deficiency, can 0000006690 00000 n 2010 Jan. 91(1):231-7. [, Huang T, Chen Y, Yang B, et al. Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation. However, another analysis showed no associations between folate intakes from both food and dietary supplements and depression among 1,368 healthy Canadians aged 6784 years [118]. The study by Daly, et al. NTP monograph: identifying research needs for assessing safe use of high intakes of folic acid. 2012 Aug. 31(4):448-54. This was after I stopped taking ALL multivitamins for 3 weeks!!! Join the ODS Email List. However, in a subset of women with a low baseline dietary intake of B vitamins, supplementation significantly slowed the rate of cognitive decline. Benoist BD: Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Br J Haematol. Maternal folate deficiency is associated with fetal neural tube defects (NTDs). 0000002547 00000 n 0000010880 00000 n Folate intake and colorectal cancer risk: a meta-analytical approach. [, Czeizel AE, Puho EH, Langmar Z, et al. However, in one of the studies included in the analysis, folic acid supplementation (1,000 mcg/day) significantly increased the risks of having three or more adenomas and of noncolorectal cancers, although it had no effect on colorectal cancer risk [71]. Another risk involves the use of folic acid to treat a folate deficiency, but because a folate deficiency closely resembles a vitamin B-12 deficiency, if the B- 12 deficiency goes undiagnosed, the treatment can lead to irreversible brain damage. Am J Clin Nutr 2018;107:139-42. Serum folate concentrations are commonly used to assess folate status; a value above 3 ng/mL indicates adequacy [1,2,9]. 2018 Jun 23. 0000003730 00000 n I hope that helps! endstream endobj 283 0 obj <>stream Evaluation of macrocytic anemias commonly requires measurement of the serum concentration of both vitamin B12 and folate; ideally they should be measured at the same point in time. Stover PJ. [, Troen AM, Mitchell B, Sorensen B, et al. Therefore, we sought to Furthermore, folate supplements might reduce serum levels of these medications, so patients taking antiepileptic drugs should check with their health care provider before taking folate supplements [166]. In adults, mean erythrocyte folate concentrations range from 216 to 398 ng/mL, also indicating adequate folate status [31]. Another clinical trial included 5,522 patients aged 55 years or older with vascular disease or diabetes from various countries (including the United States and Canada) that had a folic acid fortification program and some that did not [88]. Int J Cancer. Washington DC: National Academy Press; 1998. [, Vollset SE, Clarke R, Lewington S, et al. Before your visit, write down questions you want answered. [Full Text]. What would cause a folate (folic acid) level of 19.5, B12 of over 1000, iron of 59, ubc 325, tibc 384, transferrin saturation 15.4, ferritin 50.1 & hgb of 13.5? Blount BC, Mack MM, Wehr CM, et al. Nutrients 2011;3:370-84. H\@FyZv/jAZp1?=Ib\s-*_nVM;CT]]>&Tu?h_vmoo>6M&5\>fJ]kM0aoL>>u{&F*]]]sL>33]YqcCgpl )4%4r$[@+B.+rP K9-Fr f3a&93`0fL0s f3a&3,/,Y^XgyeyOR)R. Neurology 2014;83:2158-66. 2009 May. Supplementation did, however, significantly reduce the risk of stroke by 25%. 1 doctor answer 1 doctor weighed in Antiepileptic medications, such as phenytoin (Dilantin), carbamazepine (Carbatrol, Tegretol, Equetro, Epitol), and valproate (Depacon), are used to treat epilepsy, psychiatric diseases, and other medical conditions. Since November 1, 1998, the Canadian government has also required the addition of 150 mcg folic acid/100 g to many grains, including enriched pasta, cornmeal, and white flour [6,16]. [, Plumptre L, Masih SP, Ly A, et al. The most thorough research has focused on folates effect on the development of colorectal cancer and its precursor, adenoma [1,55,60]. I)(*H/f|3a.Lnax#/7P^5E Lonn E, Yusuf S, Arnold MJ, et al. [, Cleare A, Pariante CM, Young AH, et al. 2005 Feb. 118(2):161-7. 0000250363 00000 n [, He H, Shui B. Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies. [QxMD MEDLINE Link]. Another clinical trial in the United Kingdom randomized 475 adults with moderate to severe depression who were taking antidepressant medications to either 5,000 mcg folic acid or placebo daily for 12 weeks in addition to their antidepressants [126]. 0000007804 00000 n Please confirm that you would like to log out of Medscape. Centers for Disease Control and Prevention. Before entering the bloodstream, the enzyme dihydrofolate reductase reduces the monoglutamate form to THF and converts it to either methyl or formyl forms [1]. Cardiovascular disease and stroke Folate status and colorectal cancer risk: a 2016 update. [, Toole JF, Malinow MR, Chambless LE, et al. Even moderate alcohol consumption of 240 ml (8 fluid ounces) red wine per day or 80 ml (2.7 fluid ounces) vodka per day for 2 weeks can significantly decrease serum folate concentrations in healthy men, although not to levels below the cutoff for folate adequacy of 3 ng/ml [35]. Int J Cancer 2005;113:825-8. Emmanuel C Besa, MD Professor Emeritus, Department of Medicine, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University Ray JG, Laskin CA. [QxMD MEDLINE Link]. An analysis of 10,789 participants from this trial found that folic acid supplementation significantly reduced the risk of stroke by 73% among those who had a low platelet count and an elevated homocysteine level (increasing their risk of stroke) but had no significant effect on participants with a high platelet count and low homocysteine level [95]. In addition, women with the 677C>T MTHFR polymorphismwhich is more common in Hispanics than Caucasians, Asians, and African Americansmight have an increased risk of NTDs [1,3,27,40]. 2011 Oct 12. Carmel R. Folic acid. Hl=o07P3>;^, K)8#?Np"s{R4l06 Q"1 *0 Folic acid (also known as folate) is a water-soluble vitamin that, along with vitamin B12 belongs to the group of B-complex vitamins. WebFolic acid helps form red blood cells and produce DNA that stores genetic codes. Am J Clin Nutr 2009;90:1449-50. We are vaccinating all eligible patients. I have hemochromatosis which is high iron. About 25% of Hispanics, 10% of Caucasians and Asians, and 1% of African Americans are homozygous for the 677C>T MTHFR polymorphism [27]. |Contact Us. Chang JY, Wang YP, Wu YC, Cheng SJ, Chen HM, Sun A. Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. Genes Nutr. Am J Clin Nutr 2011;94:666S-72S. MMWR Morb Mortal Wkly Rep 2015;64:1-5. [, Selhub J, Morris MS, Jacques PF, et al. However, some people are at risk for folate toxicity from dietary supplements, and fortified foods. The following groups are among those most likely to be at risk of folate inadequacy. Have read that can have symptoms and yet high levels of B12 and feel some better after taking B12 (am trying methyl B12 which is helping). It also aids with tissue and cell growth in addition to the making of DNA, which contains genetic information. Diagnosis is confirmed by the presence of low serum folate and/or low red blood cell folate. Daily doses greater than 1 mg do not enhance the hematologic effect, and most of the excess is excreted unchanged in the urine. DRI is the general term for a set of reference values used for planning and assessing nutrient intakes of healthy people. The authors of a 2012 meta-analysis of 19 randomized controlled trials that included 47,921 participants concluded that B-vitamin supplementation has no effect on the risk of cardiovascular disease, myocardial infarction, coronary heart disease, or cardiovascular death, although it does reduce the risk of stroke by 12% [86]. If we have high levels of b12 and folate are we not supposed to supplement with those until levels come down? JAMA 2015;313:1321-2. Preterm birth, congenital heart defects, and other congenital anomalies J Nutr 2006;136:189-94. [. [, Bailey RL, Dodd KW, Gahche JJ, et al. 0000008184 00000 n The RBCs varied from 4.28 to 5.03 10 12 per liter (reference range, 4.10-5.70 10 12 per liter). 0000003677 00000 n You are more likely to have this type of anemia if you: The symptoms of folate-deficiency anemia may look like other blood conditions or health problems. [QxMD MEDLINE Link]. [, Neuhouser ML, Cheng TY, Beresford SA, et al. [, Jenkins DJA, Spence JD, Giovannucci EL, et al. 0000249226 00000 n JAMA 2004;291:565-75. Here's some information about this from a natural practitioner who effectively deals with this regularly. Low folate status has been linked to depression and poor response to antidepressants in some, but not all, studies. 0000249128 00000 n In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. 12:14. Although most people consume adequate amounts of folate, I suppose that he has functional B12 deficiency, but I am wondering how to corect this. Eur J Gastroenterol Hepatol 2016;28:1357-64. Author Study design Results; Scholl et al (8)Prospective, observational study of folate from diet and supplements, and serum folate (n = 832)Women with low folate intake (240 g/d) had >3 times greater preterm delivery and infant low birth weight than women with folate intake >240 g/d (P < 0.05).Risk of preterm delivery without Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. 2017 Mar. 244 0 obj <> endobj [, Ortiz Z, Shea B, Suarez Almazor M, et al. History of changes to this fact sheet, U.S. Department of Health & Human Services, Division of Program Coordination, Planning, and Strategic Initiatives, Strengthening Knowledge and Understanding of Dietary Supplements, My Dietary Supplement and Medicine Record, Analytical Methods and Reference Materials (AMRM), NIH Consortium for Advancing Research on Botanical and Other Natural Products (CARBON) Program, Computer Access to Research on Dietary Supplements (CARDS) Database, Dietary Supplement Ingredient Database (DSID), ODS Funding of Grants & Administrative Supplements: FAQ, Administrative Supplements for Validation Studies of Analytical Methods, Staff Bios, Publications, and Presentations, Federal Working Group on Dietary Supplements, NIH Dietary Supplement Research Coordinating Committee, dementia, cognitive function, and Alzheimers disease, preterm birth, congenital heart defects, and other congenital anomalies. Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Folate, methionine, and alcohol intake and risk of colorectal adenoma. Any medical decisions should be made with the assistance of a medical professional. Clin Chem. Coull BM, Malinow MR, Beamer N, Sexton G, Nordt F, de Garmo P. Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke. [Full Text]. `|F3M/vY*FiTU`aa&e{>\qu)q!) zT? poy7B!>K[XnJ` M J Am Heart Assoc 2018;7. r\a W+ You take certain medicines, such as some used for seizures. Folic acid intake from fortification in United States exceeds predictions. [, Gloria L, Cravo M, Camilo ME, et al. [, Sarris J, Murphy J, Mischoulon D, et al. Am J Clin Nutr 2011;94:1053-62. Panel A: FVB females entered the experiments at the age of 1012 weeks, after diabetes induction by STZ, whereas NOD females were used between the ages of 1217 weeks, depending on development of [, Tian T, Yang KQ, Cui JG, et al. I can't find anything about high b12 and high folic. Another reason is that it works in conjunction with vitamin B12. Travelling since 2015 had a b12 test which was high dr said he was not concerned because I am taking supplement . My folate is at 24.0 and the high range should be 5.5. Updated estimates of neural tube defects prevented by mandatory folic Acid fortification - United States, 1995-2011. [, Mason JB, Tang SY. Autism spectrum disorder Investigation of suspected folate deficiency, The term folate refers to all derivatives of folic acid. [. JAMA 2008;300:1774-83. J Am Acad Dermatol 1993;28:466-9. For a reader-friendly overview of Folate, see our consumer fact sheet on Folate. 0000249378 00000 n [, Giovannucci E, Stampfer MJ, Colditz GA, et al. However, remember that it is also not advisable to take it in high quantities. Evidence of folic acid and folate in the prevention of neural tube defects. 2012 Mar. A folic acid test is done by taking a small amount of blood from a vein in the hand or arm. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Pediatrics 2006;117:1394-9. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Reynolds EH. Redness. Difficulty breathing. Excess folic acid is excreted in urine. A high folate intake can mask vitamin B-12 deficiency until its neurological effects become irreversible. This can typically be remedied by taking a supplement containing 100 percent of the daily value of both folic acid and vitamin B-12. Always see yourhealthcare provider for a diagnosis. Some, but not all, observational studies have also found correlations between low serum folate concentrations and both poor cognitive function and higher risk of dementia and Alzheimers disease [79,100,101,103,105]. U. S. Preventive Services Task Force, Bibbins-Domingo K, Grossman DC, et al. 149:110543. You are pregnant. [, Malouf R, Grimley Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Huang T, Chen Y, Yang B, Yang J, Wahlqvist ML, Li D. Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Unmetabolized folic acid is detected in nearly all serum samples from US children, adolescents, and adults. Intestinal blind loop syndrome can cause elevated serum folate levels. Kim YI, Pogribny IP, Basnakian AG, et al. UL/ CUL Constant Volatge LED Power Supply, UL/ CUL Constant Current LED Power Supply, Room 8055, 5th floor. Research has not established the precise nature of folates effect on carcinogenesis, but scientists hypothesize that folate might influence cancer development through its role in one-carbon metabolism and subsequent effects on DNA replication and cell division [55,56]. Elevated plasma homocysteine levels are helpful in situations of diagnostic difficulty. 2015 Sep. 145 (9):2123-9. 66(6):544-51. Serum gel tubes should be centrifuged within 2 hours of collection. JAMA 2015;313:1325-35. [, de Vogel S, Dindore V, van Engeland M, et al. [, Morris MS, Jacques PF, Rosenberg IH, Selhub J. Arch Intern Med 2012;172:540-7. 0000194109 00000 n trailer Lancet 2007;369:208-16. As the initial test, ruling out cobalamin deficiency is very important because deficiency of folic acid and vitamin B12 produce overlapping neurologic manifestations, and both cause megaloblastic anemia, but folate treatment will not improve neurologic abnormalities due to cobalamin deficiency. Medicina (Kaunas). About 85% of supplemental folic acid, when taken with food, is bioavailable [2,4]. Elevation of serum levels of B12 and folate are consistent with a methylation deficit. [, Berry RJ, Crider KS, Yeargin-Allsopp M. Periconceptional folic acid and risk of autism spectrum disorders. [QxMD MEDLINE Link]. [, Stamm RA, March KM, Karakochuk CD, et al. JAMA 2010;303:2486-94. [, Dary O. Nutritional interpretation of folic acid interventions. All Rights Reserved. It is vital for the making of healthy red blood cells. In a significant number of people high levels of B12 can cause a functional B12 deficiency (your body reacts to the high levels of B12 making the mechanism that allows B12 to get into your cells much less efficient so you are deficient at the cellular level though the levels in your blood are high. May accelerate age-related mental decline. Food Standards: Amendment of Standards of Identity For Enriched Grain Products to Require Addition of Folic Acid. WebFolate (folic acid) overview for health professionals. I scoured the literature on hemachromatosis and could find nothing that states high folate and B12 levels are associated with hemachromatosis. The authors of a 2017 systematic review concluded that folic acid supplementation protected users from NTDs in studies conducted before food fortification with folic acid began in the United States [142]. He/she may also refer if one is having vitamin B-12 deficiency symptoms. His Hb and Hct levels have fluctuated over a 2-year period from 17.4 to 18.1 g/dL (reference range, 13.0-17.0 g/dL) and from 52.7% to 54.4% (reference range, 39%-51%), correspondingly. Do not order on patients who have recently received methotrexate or other folic acid antagonists. [, Kang JH, Cook N, Manson J, et al. These doses exceed the UL and should be taken only under medical supervision [143]. If her level is high, ask for a prescription for CerefolinNAC or another medical food that delivers the ACTIVE FORM of b12 and folate.Then ask to have her homocysteine level checked every 3 to 6 months. Excess folic acid intake may speed age-related Copy and paste it, adding a note of your own, into your blog, a Web page, forums, a blog comment, [, Levine SZ, Kodesh A, Viktorin A, et al. Burr NE, Hull MA, Subramanian V. Folic Acid Supplementation May Reduce Colorectal Cancer Risk in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. - you have a B12 deficiency (folate sometimes builds up un-metabolised if you don't have enough B12, they work together) - you have problems metabolising folate / Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms--the Beyond Ageing Project: a randomized controlled trial. Red blood cell folate and plasma folate are not associated with risk of incident colorectal cancer in the Women's Health Initiative observational study. N Engl J Med 2006;354:1567-77. If a digestive tract problem causes your anemia, your provider may treat that first. A meta-analysis of six randomized controlled trials that included a total of 25,738 men found that the risk of prostate cancer was 24% higher in men receiving folic acid supplements than those taking a placebo [78]. His write-ups aim at educating people not by just giving facts but by infusing human touch. The association was statistically significant in females, but not in males. [, Shaw GM, O'Malley CD, Wasserman CR, et al. BMC Public Health 2007;7:41. 0000003215 00000 n The activity of dihydrofolate reductase varies greatly among individuals [3]. I suffer from a genetic condition called genetic haemochromatosis or GH. my daughter and I had smilar proplem. Food is unable to pass through the loop, and digestive juices stagnate. Your recommended daily intake of folate depends on your age and other factors: Maternal folate status as a risk factor for autism spectrum disorders: a review of existing evidence. We just learned that it can be caused by a B1 deficiency. WebThe people with low B12 and high folate levels were more likely to have anemia than did people with low B12 levels and normal folate levels. 0000008089 00000 n Also know what the side effects are. The slow moving food and waste will begin to ferment, creating conditions for bacterial overgrowth, and results in a malabsorption of essential nutrients. Elsevier; 2018:chap 37. Gastroenterol Clin North Am. B vitamin and/or omega-3 fatty acid supplementation and cancer: ancillary findings from the supplementation with folate, vitamins B6 and B12, and/or omega-3 fatty acids (SU.FOL.OM3) randomized trial. One of the most important folate-dependent reactions is the conversion of homocysteine to methionine in the synthesis of S-adenosyl-methionine, an important methyl donor. JAMA. [, Shane B. Folate-responsive birth defects: of mice and women. Based on the metabolic interactions between folate and vitamin B12, the FNB established a UL for the synthetic forms of folate available in dietary supplements and fortified foods (Table 3) [2]. In addition, it may be suggested to know how far a treatment procedure is working for any of the above said conditions-anemia and folic acid and vitamin B-12 deficiencies. [QxMD MEDLINE Link]. WebApproximately 20% of the folate absorbed daily is derived from dietary sources; the remainder is synthesized by intestinal microorganisms. In most cases, serum folate testing alone is sufficient for assessment of folate status, but if there is strong clinical suspicion of folate deficiency and the serum folate level is normal and cobalamin deficiency has been ruled out, the red blood cell (RBC) folate level may be measured. Fanghua Guangyuan Electronics Co., Ltd. Any increase in serum folate associated with feeding is likely to be transient, or temporary. N Engl J Med 1981;305:1513-7. [, Sweeney MR, McPartlin J, Scott J. Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum. endstream endobj 245 0 obj <>/PageMode/UseOutlines/Names 250 0 R/ViewerPreferences<>/Outlines 323 0 R/Metadata 45 0 R/AcroForm 249 0 R/Pages 44 0 R/PageLayout/SinglePage/OpenAction 246 0 R/Threads 247 0 R/StructTreeRoot 47 0 R/Type/Catalog/Lang(EN)>> endobj 246 0 obj <> endobj 247 0 obj [248 0 R] endobj 248 0 obj <> endobj 249 0 obj <>/Encoding<>>>>> endobj 250 0 obj <> endobj 251 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/ExtGState<>>>/Type/Page>> endobj 252 0 obj [253 0 R 257 0 R] endobj 253 0 obj <>/AP<>>> endobj 254 0 obj <>/ProcSet[/PDF/Text]>>/Type/XObject/BBox[0.0 0.0 151.451 20.7249]/FormType 1>>stream 2023 HealthCheckUp.com. Evidence also indicates that folate might play a dual role in cancer initiation and progression [57]. Serum folate measurement is preferred over RBC folate measurement due to considerable analytic variability (coefficient of variation) of assays. 0000249654 00000 n Red blood cells carry oxygen to all parts of your body. Findings from these Norwegian trials have raised concerns about folic acid supplementations potential to raise cancer risk. Lack of either folic acid or Vitamin B-12 can lead to anemia as such this test may also be recommended to know the presence of anemia symptoms. 0000006844 00000 n Am J Clin Nutr 2003;77:658-62. [, Valera-Gran D, Navarrete-Munoz EM, Garcia de la Hera M, Fernandez-Somoano A, Tardon A, Ibarluzea J, et al. [, Kelly P, McPartlin J, Goggins M, et al. [, Aisen PS, Schneider LS, Sano M, et al. J Nutr Biochem 1999;10:66-88. Folate intake, and therefore increased serum folate levels, is not associated with any health risk, and the risk of toxicity from supplement-related folic acid intake is extremely low. Arch Intern Med 2007;167:21-30. [, Williams LJ, Rasmussen SA, Flores A, et al. [, Lamers Y, Prinz-Langenohl R, Bramswig S, et al. [48] The reference range for serum cobalamin is 200-900 pg/mL. My B12 is high too. This section focuses on seven diseases and disorders in which folate might play a role: autism spectrum disorder; cancer; cardiovascular disease and stroke; dementia, cognitive function, and Alzheimers disease; depression; NTDs; and preterm birth, congenital heart defects, and other congenital anomalies. Is high homocysteine level a risk factor for cognitive decline in elderly? 1 mcg DFE = 0.6 mcg folic acid from fortified foods or dietary supplements consumed with foods, 1 mcg DFE = 0.5 mcg folic acid from dietary supplements taken on an empty stomach. [, Roberts E, Carter B, Young AH. Fairbanks VF, Klee GG: Biochemical aspects of hematology. [, Clarke R, Halsey J, Lewington S, et al. Bailey RL, Dodd KW, Gahche JJ, Dwyer JT, McDowell MA, Yetley EA. Almost all children aged 1 to 8 years who consume at least 200 mcg/day folic acid from dietary supplements have total intakes that exceed the UL [18]. Ann Intern Med. [, Scholl TO, Johnson WG. This means we have a genetic mutation whereby a genetic change has taken place in the digestive system which means we overload with iron from our diet.
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