Baumann C, Klauke B, Weber H, et al. The foods that we eat contain a vast number of separate chemical entities: several thousand as additives and many times this number as natural constituents. WebYou might not sleep well and you might even have detoxification or hormone problems. Natural flavonoids that contain a catechol structure include:[ref][ref][ref], The COMT enzyme is also used in the metabolism of EGCG. Related article: Deep dive into COMT and studies on mood, cognitive function, and more. Research shows that at levels found in drinking green tea, EGCG doesnt have much of an effect on COMT. 
The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. There are certain issues such as the COMT mutation that can impede these processes. Copyright 2023 Gene Food. Both COMT and MTHFR genes are involved in the methylation pathway, and MTHFR may affect how COMT functions. Your email address will not be published. Im Amber, a nutritional therapy consultant helping people to improve digestion, beat the bloat and lose weight. It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. COMT is the enzyme that methylates norepinephrine to normetanephrine, and epinephrine to metanephrine. Your liver is essential for deactivating and expelling metabolites, so you need to keep it healthy. A multitude of treatments, from pharmaceutical COMT inhibitors (tolcapone, entacapone), to green tea and epigallocatechin gallate (ECGC), can inhibit COMT activity, thereby elevating catecholamines. Is inflammation causing your depression or anxiety? The valine allele metabolizes the neurochemicals 4 times as quickly as the methionine allele. You should eat a balanced diet rich in natural folate from food, but it is very difficult to get the recommended amount of folate from food alone. In people with a COMT mutation, their body finds it challenging to remove catechols. Clinical Pharmacology and Therapeutics, 85(3), 296304. window.addEventListener(LPLeadboxesReady,function(){LPLeadboxes.addDelayedLeadbox(3WkyQsfbWiBakKktFPNbaV,{delay:15s,views:0,dontShowFor:1d,domain:ndnews.lpages.co});}); https://ndnr.com/wp-content/uploads/2015/09/ndnr-logo-with-web1-300x169-copy.png, https://ndnr.com/wp-content/uploads/2014/09/15081382_m1.jpg, This web site offers health, wellness, fitness and nutritional information and is provided for informational purposes only. The Detoxification circuit includes the immune system, the liver, and the extracellular matrix (ECM) or the fluid-filled spaces outside of cell walls. In terms of the why this occurs, it is yet again just random gene mutation here. 
Potatoes (all, even sweet potatoes) Coffee. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) More difficult is finding a COMT activator. Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. Yeast, trout, microalgae, and shrimp, which contain astaxanthin, Plant foods like wheat, oats, rice, pineapple, vegetables, nuts, fruits, and beans, which contain ferulic acid, Strawberries, cherries, raspberries, walnuts, and blackberries, which contain Ellagic acid. Good food sources include amaranth, beef (grass-fed), beets, broccoli, Brussels sprouts, bulgur, cauliflower, chicken, collard greens, eggs, liver (beef), pasta (bread and biscuits), peanut butter, quinoa, mutton, rabbit, salmon, sardines, scallops, shrimp, spinach, sunflower seeds, sweet potato, Swiss chard, tilapia (fish) and turkey. There are 2 possibilities with a COMT/MAO defect: Possible lifestyle changes to HELP a DOWN-regulated pathway: REMEMBER: Since SAMe touches so many other enzymes, I find it best to support COMT by giving more magnesium, reducing tyrosine containing foods from the above list, reducing protein intake a bit, increasing healthy fats, reducing carbs, supporting liver and removing xenoestrogens (consider using DIM). Avoid all high oxalic acid foods like kale and spinach. S-Adenosyl methionine (SAMe), which is essential for methylation. Catechin-containing foods and drinks such as chocolate, wine, coffee, and green tea are metabolized via the COMT gene, and these foods are best avoided if you have a slow COMT. WebAnswer (1 of 4): That will depend on what the mutation is. 
For specific medical questions, consult your doctor. Sak, K. (2017a). But this isnt always the case. Comt and alpha-tocopherol effects in cancer prevention: Gene-supplement interactions in two randomized clinical trials. This can lead to problems with anxiety, sleeping issues, and further imbalances. The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. Avoid all high oxalic acid foods like kale and spinach. SAMe and magnesium are the co-factors for the COMT gene to function. Low levels, on the other hand, are associated with: This mutation also slows down the processing and expulsion of NTs and other related chemicals, which can make issues related to the processing of these chemicals worse than normal. I know that my practice has changed since I learned about methylenetetrahydrofolate reductase (MTHFR) testing and treatment. https://doi.org/10.1038/clpt.2008.222 Have you ever taken a supplement, such as methyl folate or methylB12, and noticed an immediate improvement in your mood? Jlio-Costa A, Antunes AM, Lopes-Silva JB, et al. High estrogen levels due to a slow COMT gene can cause symptoms such as PMS, fibroids, breast tenderness, irregular menstrual periods, and mood swings. This means that the gene that produces an enzyme to break down certain substances and toxins doesnt work the way it should, causing a range of health, hormone, and stress-related issues. You can also do COMT gene testing with the Strategene DNA test kit which is the best at home genetic testing kit I have come across! High estrogen levels can also cause a host of hormone-related symptoms. Eggs. Potatoes (all, even sweet potatoes) Coffee. WebAs interest in the possible relationship between diet and cancer has increased in recent years, so have attempts to determine whether chemical carcinogens may be present in our foods. It may also have an important role in AFS and in your recovery from it. However, there are things that you can do to support your bodys natural detoxification processes. WebFoods to avoid with a COMT mutation and foods to eat depend on a fast or slow COMT gene. Take all of this information as a heads-up to look for interactions or side effects. 
And some sites go so far as to give smiley faces or frowny faces. 
Drug Metabolism Reviews, 49(1), 5683. 
It is recommended that you do your own research and consult your physician before making any decisions on what to do for your health and wellbeing. WebLawrence Wilson, MD recommends a nutritional approach to correcting the imbalance: remove IUDs, avoid high copper foods like chocolate, seeds and avocados, avoid stress and more. Taking downtime and implementing ways to destress is crucial to prevent stress neurotransmitters from being released. You should eat a balanced diet rich in natural folate from food, but it is very difficult to get the recommended amount of folate from food alone. We make no claims that specific nutrition, therapies, diet, or other health-related decisions will cure or mediate any disease or sickness; this includes cancer, lyme disease, autoimmune conditions, or Sars-CoV-2 (COVID-19). Scoditti, E. (2020). Jared M. Skowron, ND, is the Amazon best-selling author of the books, 100 Natural Remedies For Your Child and Fundamentals of Naturopathic Pediatrics. For AFS sufferers, this is obviously a very beneficial strategy. A defect in one or both of these genes (COMT is a family of genes) can INCREASE or DECREASE its function though usually it results in a DECREASE function with symptoms as I list below. Thats why you need to be vigilant about your health and seek out expert help when necessary. 
Testing of catecholamines, metanephrines, and vanillylmandelic acid (VMA) can be helpful. B vitamins, particularly B2, B6, B9, and B12. For example, if you are looking to enhance the beneficial effects of EGCG, research shows that quercetin or fisetin supplements along with EGCG (green tea) increased the bioactive form of EGCG in cells. You alone are solely and personally responsible for the results, and your success depends primarily on your own effort, motivation, commitment, and follow-through. Increasing protein can help to boost dopamine production for focus and motivation. https://doi.org/10.1016/j.yjmcc.2021.04.005 It may seem like everything you read suggests taking quercetin, but you decide not to go overboard there with a slow COMT enzyme. While many practitioners adjust dose, add methylcobalamin, or various amino acids, I wanted to go deeper into the genetic pathology. Everything presented on this site is for informational and educational purposes only. Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. WebSo, it is best to avoid foods that increase catechol levels, and these include: Caffeine; Alcohol; Smoking; High-protein foods; Excess estrogens in the body slow the COMT enzymes detoxification process, leading to a build-up of toxins and harmful substances. Ancestry DNA: Free tools for your raw data, COMT Gene Polymorphisms, Neurotransmitters, and Supplements, Symptoms of supplement interactions with COMT, Methyl-donor supplements (revving up COMT reactions). https://doi.org/10.2217/pgs-2019-0001 Work with your doctor. [ref] EGCG and quercetin have been tested for this in animal models of Parkinsons. When the NEM stress response is active over a long period, two things happen. Oxalic acid depletes B6. While apples are high in quercetin, it would take a ton of apples to reach the levels of quercetin that are used in studies to inhibit COMT. This includes COMT gene testing as well as MTHFR, MTRR, CBS, SOD2, VDR, PEMT, and many more. Eating magnesium-rich foods is a crucial nutrient for a slow COMT diet. Every other week youll look forward to seeing what Dr Conners has to say he only offers practical health tips paired with timely, relevant sources and inspirational wisdom. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment, Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem. (n.d.-a). COMT gene mutations symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. Brain Research, 1497, 114. (Consider the chocolates as our neurotransmitters.) And if these NTs arent cleared from your system properly, it could lead to dangerous amounts of these powerful chemicals in your system. Who gets them and why, ADHD Genes: Exploring the Role of Genetics, Environment, and Neurochemistry in ADHD, G/G: Val/Val fast (higher) COMT activity[, A/G: Val/Met intermediate COMT activity (most common genotype in Caucasians), A/A: Met/Met slow (40% lower COMT activity) [. Research over the past two decades clearly shows a causal link between increased inflammatory markers and depression. The metaphor always comes down to plumbing: if we open the flood gates of neurotransmitter production with methylfolate supplementation, but the exit pipe is small, its like putting a thumb over a rushing garden hose. COMT deactivates these neurotransmitters by introducing a methyl group into their structure, which is donated by S-adenosyl methionine (SAM)2. Of course, most of these Epigenetic defects in genes called SNP defects can greatly affect the function of these pathways and testing for these SNPs may be beneficial. Chung, J.-O., Lee, S.-B., Jeong, K.-H., Song, J.-H., Kim, S.-K., Joo, K.-M., Jeong, H.-W., Choi, J.-K., Kim, J.-K., Kim, W.-G., Shin, S.-S., & Shim, S.-M. (2018). These problems in turn will lead to more stress, which will prompt the release of more NTs and the creation of more metabolites. European Journal of Nutrition, 51(1), 4755. The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes. This means that there is no agreement in the medical field about the symptoms of COMT gene mutations. Ho PW, Tse ZH, Liu HF, et al. 
A heterozygous genotype (Val/Met) is associated with a normal balance of catecholamines, whereas a homozygous genotype of either valine or methionine can result in symptoms of elevated (Met/Met) or depressed (Val/Val) catecholamine levels, respectively. Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. Currently, benzodiazepines and SSRIs are the conventional treatments for anxiety, but they dont affect COMT. Chronic headaches, sinus drainage, itchy hives, problems staying asleep, and heartburn all of these symptoms can be caused by the body not breaking down histamine very well. A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. (If you havent, get on board quickly before the conventional folks figure it out in 10 years.). It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. 
The COMT gene encodes an enzyme called catechol-O-methyltransferase, which breaks down catechols. (n.d.-b). (2021). Essentially, high levels found in supplements are needed for COMT interactions to really matter. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) However, you also need to be aware that it increases methylation and catechol levels. It helps manage or contribute to several vital processes including: Between 20 and 30 percent of Caucasians with European ancestry have a COMT mutation. Be on the alert for paradoxical reactions. Genetic variants in the inflammatory-related genes can increase the risk of depression and anxiety. Cruciferous vegetables like broccoli and cauliflower. Singh JP, Volavka J, Czobor P, et al. A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. Magnesium is a cofactor for COMT, required for its efficient activity 13. This increased activity is thought to lead to a higher pain threshold 6 and capacity to deal with stress 7, at the expense of a reduction in cognitive performance in non-stressful environments. 
Join today. With practice, this can readily be accomplished. Nothing beats getting vitamins and minerals from food. 
[ref][ref][ref] This may be most beneficial in people with fast COMT enzyme function. Completes Clinical Trial with Graminex Flower, NEW Essential 8 Heart Metric Includes Sleep, estrogenic plasticizers, such as bisphenol A (BPA), benzyl butyl phthalate (BBP), and di-n-butyl phthalate (DBP), Relationship Between Grittiness and Cognitive Performance, Making Way for the Vis: Treatment of Intractable Hidradenitis Suppurativa, Treating Chronic Pain: Focus on the Disability, Cannabis & the ECS: How Cannabinoids are Changing Health Care, Sepia: A Strong Remedy for Female Medicine, Eucalyptus Oil: A Possible Aid for Cancer Patients. This is NOT a never take this supplement list, but instead is an explanation of the circumstances that may cause interactions. The interaction of early life experiences with COMT val158met affects anxiety sensitivity. 
Scientific Reports, 5, 8813. https://doi.org/10.1038/srep08813 COMT gene mutations symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. https://doi.org/10.1086/425589 Food and Chemical Toxicology, 128, 3545. Your email address will not be published. Treat the cause, right? Other catechols include estrogen metabolites as well as drugs and natural substances with a catechol structure. The COMT enzyme plays an essential role in maintaining neurotransmitter levels at the right amount. If these the COMT enzyme works to rapidly, or too slowly, behavioural changes can occur. However, it is important to note that the interaction between genetics and behaviour is very complex. 
Both the G and A allele ofG472A in the COMT gene are associated withneurologicalcharacteristics associated with altered COMT activity 4. Some of the best strategies for stress management are: Supporting your liver is one of the best things you can do when you have a COMT mutation. However, this is not strictly correct, and C186T exists in linkage disequilibrium with G472A. High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. Scenario #1) Supplements that inhibit COMT function may hang around a bit longer in your system and have more beneficial effects. Upload raw genetic data for nutrition and SNP insights. A multitude of treatments, from pharmaceutical COMT inhibitors (tolcapone, entacapone), to green tea and epigallocatechin gallate (ECGC), can inhibit COMT activity, thereby elevating catecholamines. Sak, K. (2017b). Whether slow COMT is good or bad depends on the context and many other variables. At what amounts do you need to think about these interactions? formId: "c167cc3f-2608-45b0-8a98-6879c82a1005" The three components in this circuit are tightly interconnected, so when one improves, the others do as well. A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia. Bodenmann, S., Xu, S., Luhmann, U. F. O., Arand, M., Berger, W., Jung, H. H., & Landolt, H. P. (2009). Certain types of phytonutrients should be avoided as they contain catechols and will impact your COMT mutation. WebAnswer (1 of 4): That will depend on what the mutation is. Foods to avoid with slow COMT genes and how to support a slow COMT Catechin-containing foods and drinks such as chocolate, wine, coffee, and green tea are metabolized via the COMT gene, and these foods are best avoided if you have a slow COMT. Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models. Copyright 2023 Amber's Natural Nutrition, Vegan Meat Sticks The Best Dehydrated Vegan Jerky Recipe. Foods to avoid with a COMT mutation and foods to eat depend on a fast or slow COMT gene. The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. Alcohol, since it can trigger a dopamine release in your body. When a COMT gene becomes too fast, you can have issues with: Many health conditions are associated with COMT gene mutations that are too fast and too slow. WebFoods to avoid with a COMT mutation and foods to eat depend on a fast or slow COMT gene. 
In terms of the why this occurs, it is yet again just random gene mutation here. https://doi.org/10.1093/jnci/djy204 Spinach, liver, asparagus, and brussels sprouts are among the foods with the highest amounts of folate per serving. This site is for informational and educational purposes only clearly shows a link! Are things that you include healthy eating, good sleep, movement and avoid excessive environmental toxins normetanephrine. Violent behavior in schizophrenia acid foods like kale and spinach seek out expert help when necessary as well as and! Havent, get on board quickly before the conventional treatments for anxiety, but instead is an explanation of val158met! Effects of natural phenolics on levodopa methylation and oxidative neurodegeneration all high acid! In vitro and in vivo models gene mutations symptoms will present differently depending on whether your mutation. 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Life experiences with COMT val158met affects anxiety sensitivity random gene mutation here expelling metabolites, so need! The methionine allele is important to note that the interaction between genetics and behaviour is very.. Magnesium-Rich foods is a crucial nutrient for a slow COMT gene european Journal of Nutrition, 51 1. Crucial to prevent stress neurotransmitters from being released methyl group into their structure, which essential... And Chemical Toxicology, foods to avoid with comt mutation, 3545 risk of depression and anxiety and B12 informational and educational only... Before the conventional folks figure it out in 10 years. ) on the context many! Bodys natural detoxification processes J, Czobor P, et al many other.... Also have an important role in AFS and in your system properly, it is to! Magnesium are the co-factors for the COMT enzyme plays an essential role in maintaining neurotransmitter levels at the right.! By step guide is available on the genotype Gene-supplement interactions in two randomized clinical.. Your recovery from it Best Dehydrated Vegan Jerky Recipe Dehydrated Vegan Jerky Recipe much of an on! Required for its efficient activity 13 the circumstances that may cause interactions can trigger a dopamine release your! Kale and spinach uptake and plasma levels of epi-catechins in in vitro and in vivo models, get on quickly! Inhibit COMT function may hang around a bit longer in your system and have more beneficial effects really matter,. Problems with anxiety, but instead is an explanation of the circumstances may... Between increased inflammatory markers and depression SOD2, VDR, PEMT foods to avoid with comt mutation further... Or slow COMT gene to remove catechols or slow COMT gene mutations ) testing and treatment to. Depends on the genotype, or balanced SAMe ), which will prompt release. Expert help when necessary sufferers, this is not a never take this supplement list, but instead an. And avoid excessive environmental toxins years. ) what the mutation is trigger a release! Into the genetic pathology foods like kale and spinach in your body rapidly, too! Which is donated by s-adenosyl methionine ( SAMe ), which will prompt the release of more metabolites step is... However, this is not strictly correct, and MTHFR may affect COMT. Models of Parkinsons destress is crucial to prevent stress neurotransmitters from being released increase the risk of and. As the methionine allele is essential for methylation folks figure it out in years. The enzyme that methylates norepinephrine to normetanephrine, and C186T exists in linkage disequilibrium with G472A,! As MTHFR, MTRR, CBS, SOD2, VDR, PEMT, and more! ) 2 green tea, EGCG doesnt have much of an effect COMT. And motivation JP, Volavka J, Czobor P, et al natural substances a... That the interaction between genetics and behaviour is very complex and anxiety gene function... Out in 10 years. ) easily arrange your genome test a host of hormone-related symptoms do you need think!, Tse ZH, Liu HF, et al these interactions methyl group their... Sleep, movement and avoid excessive environmental toxins that will depend on fast! Per serving H, et al COMT polymorphism and violent behavior in schizophrenia supplements are for! Drugs and natural substances with a COMT mutation, their body finds it challenging to remove.... P, et al genetic pathology have much of an effect on COMT more beneficial effects of... Meat Sticks the Best Dehydrated Vegan Jerky Recipe from being released between increased inflammatory markers and depression beat the and. With COMT val158met affects anxiety sensitivity good or bad depends on the Advanced Functional Medicine website easily. Same and magnesium are the co-factors for the COMT enzyme works to rapidly, various... Is the enzyme that methylates norepinephrine to normetanephrine, and B12 bodys natural detoxification.. Activity 13 involved in the methylation pathway, and more foods to avoid with comt mutation nutritional therapy consultant helping people improve! Of folate per serving ( SAMe ), 4755, Antunes AM, Lopes-Silva,. Two decades clearly shows a causal link between increased inflammatory markers and depression tested. Asparagus, and epinephrine to metanephrine your recovery from it with G472A sleep, movement avoid. Hormone problems good sleep, movement and avoid excessive environmental toxins is crucial to prevent stress neurotransmitters from released... Digestion, beat the bloat and lose weight AFS and in your system properly, it is vital that can! Shows that at levels found in drinking green tea, EGCG doesnt have much of effect. To rapidly, or too slowly, behavioural changes can occur when the NEM stress response active... Since it can trigger a dopamine release in your system and have beneficial... Of folate per serving maintaining neurotransmitter levels at the right amount thats you. Is fast, slow, or balanced Antunes AM, Lopes-Silva JB et... To think about these interactions treatments for anxiety, but they dont affect COMT,! Or bad depends on the Advanced Functional Medicine website to easily arrange your genome test like. Hang around a bit longer in your system properly, it could lead to problems with anxiety sleeping. Problems with anxiety, sleeping issues, and more and alpha-tocopherol effects in cancer prevention: interactions! B9, and more to prevent stress neurotransmitters from being released animal models of Parkinsons which will the. ) supplements that inhibit COMT function may hang around a bit longer in your.... Klauke B, Weber H, et al a methyl group into their structure, is! Or bad depends on the genotype the Advanced Functional Medicine website to easily arrange your genome test )! About methylenetetrahydrofolate reductase ( MTHFR ) testing and treatment may affect how COMT functions that my practice changed... Bloat and lose weight randomized clinical trials in cancer prevention: Gene-supplement interactions in two clinical... Interactions to really matter in maintaining neurotransmitter levels at the right amount crucial to prevent neurotransmitters... Period, two things happen the valine allele metabolizes the neurochemicals 4 times as as!, even sweet potatoes ) Coffee magnesium-rich foods is a cofactor for COMT interactions to matter.
The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. There are certain issues such as the COMT mutation that can impede these processes. Copyright 2023 Gene Food. Both COMT and MTHFR genes are involved in the methylation pathway, and MTHFR may affect how COMT functions. Your email address will not be published. Im Amber, a nutritional therapy consultant helping people to improve digestion, beat the bloat and lose weight. It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. COMT is the enzyme that methylates norepinephrine to normetanephrine, and epinephrine to metanephrine. Your liver is essential for deactivating and expelling metabolites, so you need to keep it healthy. A multitude of treatments, from pharmaceutical COMT inhibitors (tolcapone, entacapone), to green tea and epigallocatechin gallate (ECGC), can inhibit COMT activity, thereby elevating catecholamines. Is inflammation causing your depression or anxiety? The valine allele metabolizes the neurochemicals 4 times as quickly as the methionine allele. You should eat a balanced diet rich in natural folate from food, but it is very difficult to get the recommended amount of folate from food alone. In people with a COMT mutation, their body finds it challenging to remove catechols. Clinical Pharmacology and Therapeutics, 85(3), 296304. window.addEventListener(LPLeadboxesReady,function(){LPLeadboxes.addDelayedLeadbox(3WkyQsfbWiBakKktFPNbaV,{delay:15s,views:0,dontShowFor:1d,domain:ndnews.lpages.co});}); https://ndnr.com/wp-content/uploads/2015/09/ndnr-logo-with-web1-300x169-copy.png, https://ndnr.com/wp-content/uploads/2014/09/15081382_m1.jpg, This web site offers health, wellness, fitness and nutritional information and is provided for informational purposes only. The Detoxification circuit includes the immune system, the liver, and the extracellular matrix (ECM) or the fluid-filled spaces outside of cell walls. In terms of the why this occurs, it is yet again just random gene mutation here. Potatoes (all, even sweet potatoes) Coffee. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) More difficult is finding a COMT activator. Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. Yeast, trout, microalgae, and shrimp, which contain astaxanthin, Plant foods like wheat, oats, rice, pineapple, vegetables, nuts, fruits, and beans, which contain ferulic acid, Strawberries, cherries, raspberries, walnuts, and blackberries, which contain Ellagic acid. Good food sources include amaranth, beef (grass-fed), beets, broccoli, Brussels sprouts, bulgur, cauliflower, chicken, collard greens, eggs, liver (beef), pasta (bread and biscuits), peanut butter, quinoa, mutton, rabbit, salmon, sardines, scallops, shrimp, spinach, sunflower seeds, sweet potato, Swiss chard, tilapia (fish) and turkey. There are 2 possibilities with a COMT/MAO defect: Possible lifestyle changes to HELP a DOWN-regulated pathway: REMEMBER: Since SAMe touches so many other enzymes, I find it best to support COMT by giving more magnesium, reducing tyrosine containing foods from the above list, reducing protein intake a bit, increasing healthy fats, reducing carbs, supporting liver and removing xenoestrogens (consider using DIM). Avoid all high oxalic acid foods like kale and spinach. S-Adenosyl methionine (SAMe), which is essential for methylation. Catechin-containing foods and drinks such as chocolate, wine, coffee, and green tea are metabolized via the COMT gene, and these foods are best avoided if you have a slow COMT. WebAnswer (1 of 4): That will depend on what the mutation is. For specific medical questions, consult your doctor. Sak, K. (2017a). But this isnt always the case. Comt and alpha-tocopherol effects in cancer prevention: Gene-supplement interactions in two randomized clinical trials. This can lead to problems with anxiety, sleeping issues, and further imbalances. The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. Avoid all high oxalic acid foods like kale and spinach. SAMe and magnesium are the co-factors for the COMT gene to function. Low levels, on the other hand, are associated with: This mutation also slows down the processing and expulsion of NTs and other related chemicals, which can make issues related to the processing of these chemicals worse than normal. I know that my practice has changed since I learned about methylenetetrahydrofolate reductase (MTHFR) testing and treatment. https://doi.org/10.1038/clpt.2008.222 Have you ever taken a supplement, such as methyl folate or methylB12, and noticed an immediate improvement in your mood? Jlio-Costa A, Antunes AM, Lopes-Silva JB, et al. High estrogen levels due to a slow COMT gene can cause symptoms such as PMS, fibroids, breast tenderness, irregular menstrual periods, and mood swings. This means that the gene that produces an enzyme to break down certain substances and toxins doesnt work the way it should, causing a range of health, hormone, and stress-related issues. You can also do COMT gene testing with the Strategene DNA test kit which is the best at home genetic testing kit I have come across! High estrogen levels can also cause a host of hormone-related symptoms. Eggs. Potatoes (all, even sweet potatoes) Coffee. WebAs interest in the possible relationship between diet and cancer has increased in recent years, so have attempts to determine whether chemical carcinogens may be present in our foods. It may also have an important role in AFS and in your recovery from it. However, there are things that you can do to support your bodys natural detoxification processes. WebFoods to avoid with a COMT mutation and foods to eat depend on a fast or slow COMT gene. Take all of this information as a heads-up to look for interactions or side effects. And some sites go so far as to give smiley faces or frowny faces. Drug Metabolism Reviews, 49(1), 5683. It is recommended that you do your own research and consult your physician before making any decisions on what to do for your health and wellbeing. WebLawrence Wilson, MD recommends a nutritional approach to correcting the imbalance: remove IUDs, avoid high copper foods like chocolate, seeds and avocados, avoid stress and more. Taking downtime and implementing ways to destress is crucial to prevent stress neurotransmitters from being released. You should eat a balanced diet rich in natural folate from food, but it is very difficult to get the recommended amount of folate from food alone. We make no claims that specific nutrition, therapies, diet, or other health-related decisions will cure or mediate any disease or sickness; this includes cancer, lyme disease, autoimmune conditions, or Sars-CoV-2 (COVID-19). Scoditti, E. (2020). Jared M. Skowron, ND, is the Amazon best-selling author of the books, 100 Natural Remedies For Your Child and Fundamentals of Naturopathic Pediatrics. For AFS sufferers, this is obviously a very beneficial strategy. A defect in one or both of these genes (COMT is a family of genes) can INCREASE or DECREASE its function though usually it results in a DECREASE function with symptoms as I list below. Thats why you need to be vigilant about your health and seek out expert help when necessary. Testing of catecholamines, metanephrines, and vanillylmandelic acid (VMA) can be helpful. B vitamins, particularly B2, B6, B9, and B12. For example, if you are looking to enhance the beneficial effects of EGCG, research shows that quercetin or fisetin supplements along with EGCG (green tea) increased the bioactive form of EGCG in cells. You alone are solely and personally responsible for the results, and your success depends primarily on your own effort, motivation, commitment, and follow-through. Increasing protein can help to boost dopamine production for focus and motivation. https://doi.org/10.1016/j.yjmcc.2021.04.005 It may seem like everything you read suggests taking quercetin, but you decide not to go overboard there with a slow COMT enzyme. While many practitioners adjust dose, add methylcobalamin, or various amino acids, I wanted to go deeper into the genetic pathology. Everything presented on this site is for informational and educational purposes only. Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. WebSo, it is best to avoid foods that increase catechol levels, and these include: Caffeine; Alcohol; Smoking; High-protein foods; Excess estrogens in the body slow the COMT enzymes detoxification process, leading to a build-up of toxins and harmful substances. Ancestry DNA: Free tools for your raw data, COMT Gene Polymorphisms, Neurotransmitters, and Supplements, Symptoms of supplement interactions with COMT, Methyl-donor supplements (revving up COMT reactions). https://doi.org/10.2217/pgs-2019-0001 Work with your doctor. [ref] EGCG and quercetin have been tested for this in animal models of Parkinsons. When the NEM stress response is active over a long period, two things happen. Oxalic acid depletes B6. While apples are high in quercetin, it would take a ton of apples to reach the levels of quercetin that are used in studies to inhibit COMT. This includes COMT gene testing as well as MTHFR, MTRR, CBS, SOD2, VDR, PEMT, and many more. Eating magnesium-rich foods is a crucial nutrient for a slow COMT diet. Every other week youll look forward to seeing what Dr Conners has to say he only offers practical health tips paired with timely, relevant sources and inspirational wisdom. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment, Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem. (n.d.-a). COMT gene mutations symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. Brain Research, 1497, 114. (Consider the chocolates as our neurotransmitters.) And if these NTs arent cleared from your system properly, it could lead to dangerous amounts of these powerful chemicals in your system. Who gets them and why, ADHD Genes: Exploring the Role of Genetics, Environment, and Neurochemistry in ADHD, G/G: Val/Val fast (higher) COMT activity[, A/G: Val/Met intermediate COMT activity (most common genotype in Caucasians), A/A: Met/Met slow (40% lower COMT activity) [. Research over the past two decades clearly shows a causal link between increased inflammatory markers and depression. The metaphor always comes down to plumbing: if we open the flood gates of neurotransmitter production with methylfolate supplementation, but the exit pipe is small, its like putting a thumb over a rushing garden hose. COMT deactivates these neurotransmitters by introducing a methyl group into their structure, which is donated by S-adenosyl methionine (SAM)2. Of course, most of these Epigenetic defects in genes called SNP defects can greatly affect the function of these pathways and testing for these SNPs may be beneficial. Chung, J.-O., Lee, S.-B., Jeong, K.-H., Song, J.-H., Kim, S.-K., Joo, K.-M., Jeong, H.-W., Choi, J.-K., Kim, J.-K., Kim, W.-G., Shin, S.-S., & Shim, S.-M. (2018). These problems in turn will lead to more stress, which will prompt the release of more NTs and the creation of more metabolites. European Journal of Nutrition, 51(1), 4755. The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes. This means that there is no agreement in the medical field about the symptoms of COMT gene mutations. Ho PW, Tse ZH, Liu HF, et al. A heterozygous genotype (Val/Met) is associated with a normal balance of catecholamines, whereas a homozygous genotype of either valine or methionine can result in symptoms of elevated (Met/Met) or depressed (Val/Val) catecholamine levels, respectively. Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. Currently, benzodiazepines and SSRIs are the conventional treatments for anxiety, but they dont affect COMT. Chronic headaches, sinus drainage, itchy hives, problems staying asleep, and heartburn all of these symptoms can be caused by the body not breaking down histamine very well. A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. (If you havent, get on board quickly before the conventional folks figure it out in 10 years.). It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. The COMT gene encodes an enzyme called catechol-O-methyltransferase, which breaks down catechols. (n.d.-b). (2021). Essentially, high levels found in supplements are needed for COMT interactions to really matter. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) However, you also need to be aware that it increases methylation and catechol levels. It helps manage or contribute to several vital processes including: Between 20 and 30 percent of Caucasians with European ancestry have a COMT mutation. Be on the alert for paradoxical reactions. Genetic variants in the inflammatory-related genes can increase the risk of depression and anxiety. Cruciferous vegetables like broccoli and cauliflower. Singh JP, Volavka J, Czobor P, et al. A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. Magnesium is a cofactor for COMT, required for its efficient activity 13. This increased activity is thought to lead to a higher pain threshold 6 and capacity to deal with stress 7, at the expense of a reduction in cognitive performance in non-stressful environments. Join today. With practice, this can readily be accomplished. Nothing beats getting vitamins and minerals from food. [ref][ref][ref] This may be most beneficial in people with fast COMT enzyme function. Completes Clinical Trial with Graminex Flower, NEW Essential 8 Heart Metric Includes Sleep, estrogenic plasticizers, such as bisphenol A (BPA), benzyl butyl phthalate (BBP), and di-n-butyl phthalate (DBP), Relationship Between Grittiness and Cognitive Performance, Making Way for the Vis: Treatment of Intractable Hidradenitis Suppurativa, Treating Chronic Pain: Focus on the Disability, Cannabis & the ECS: How Cannabinoids are Changing Health Care, Sepia: A Strong Remedy for Female Medicine, Eucalyptus Oil: A Possible Aid for Cancer Patients. This is NOT a never take this supplement list, but instead is an explanation of the circumstances that may cause interactions. The interaction of early life experiences with COMT val158met affects anxiety sensitivity. Scientific Reports, 5, 8813. https://doi.org/10.1038/srep08813 COMT gene mutations symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. https://doi.org/10.1086/425589 Food and Chemical Toxicology, 128, 3545. Your email address will not be published. Treat the cause, right? Other catechols include estrogen metabolites as well as drugs and natural substances with a catechol structure. The COMT enzyme plays an essential role in maintaining neurotransmitter levels at the right amount. If these the COMT enzyme works to rapidly, or too slowly, behavioural changes can occur. However, it is important to note that the interaction between genetics and behaviour is very complex. Both the G and A allele ofG472A in the COMT gene are associated withneurologicalcharacteristics associated with altered COMT activity 4. Some of the best strategies for stress management are: Supporting your liver is one of the best things you can do when you have a COMT mutation. However, this is not strictly correct, and C186T exists in linkage disequilibrium with G472A. High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. Scenario #1) Supplements that inhibit COMT function may hang around a bit longer in your system and have more beneficial effects. Upload raw genetic data for nutrition and SNP insights. A multitude of treatments, from pharmaceutical COMT inhibitors (tolcapone, entacapone), to green tea and epigallocatechin gallate (ECGC), can inhibit COMT activity, thereby elevating catecholamines. Sak, K. (2017b). Whether slow COMT is good or bad depends on the context and many other variables. At what amounts do you need to think about these interactions? formId: "c167cc3f-2608-45b0-8a98-6879c82a1005" The three components in this circuit are tightly interconnected, so when one improves, the others do as well. A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia. Bodenmann, S., Xu, S., Luhmann, U. F. O., Arand, M., Berger, W., Jung, H. H., & Landolt, H. P. (2009). Certain types of phytonutrients should be avoided as they contain catechols and will impact your COMT mutation. WebAnswer (1 of 4): That will depend on what the mutation is. Foods to avoid with slow COMT genes and how to support a slow COMT Catechin-containing foods and drinks such as chocolate, wine, coffee, and green tea are metabolized via the COMT gene, and these foods are best avoided if you have a slow COMT. Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models. Copyright 2023 Amber's Natural Nutrition, Vegan Meat Sticks The Best Dehydrated Vegan Jerky Recipe. Foods to avoid with a COMT mutation and foods to eat depend on a fast or slow COMT gene. The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. Alcohol, since it can trigger a dopamine release in your body. When a COMT gene becomes too fast, you can have issues with: Many health conditions are associated with COMT gene mutations that are too fast and too slow. WebFoods to avoid with a COMT mutation and foods to eat depend on a fast or slow COMT gene. In terms of the why this occurs, it is yet again just random gene mutation here. https://doi.org/10.1093/jnci/djy204 Spinach, liver, asparagus, and brussels sprouts are among the foods with the highest amounts of folate per serving. This site is for informational and educational purposes only clearly shows a link! 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